The laboratory members can evaluate :

– the psychiatric and psychopathological clinic

– cognitive and behavioural performance of participants through interviews, questionnaires and neuropsychological tests completed face-to-face and via the Internet.

– access to physiological measurements by portable sensors

We have developed database expertise to develop new integrative modelling, with psychometric, psychiatric, neuropsychological, and MRI imaging data.

Denoising and harmonisation methods, machine learning (AI), algorithmic modelling, are experimented in collaboration in situ with mathematicians from the Borelli centre.

 

Three imaging techniques have been adapted to explore the brain of subjects with different conditions :

1/ MRI (Magnetic Resonance Imaging) to study the morphology of the brain,

2/ Functional MRI (fMRI) to study brain function,

3/ PET (Positron Emission Tomography) to explore neurochemistry.

The Unit, in collaboration with the methodological teams of the CEA, at the Service Hospitalier Frédéric Joliot (Orsay) and at Neurospin (Saclay), has contributed to the development of new computerised means of analysing brain morphometry. Based on the automatic segmentation of anatomical and diffusion images, it is now possible to analyse the fine anatomy (volume and shape) of each cortical sulcus and white matter fibre bundles throughout the brain.

The unit participated in the implementation of image acquisition and processing methods for the study of anatomical connectivity by diffusion MRI. These different methodological implementations are integrated into the Brainvisa (http://brainvisa.info).