{"id":1692,"date":"2022-08-01T11:51:42","date_gmt":"2022-08-01T10:51:42","guid":{"rendered":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/?page_id=1692"},"modified":"2022-08-03T15:04:14","modified_gmt":"2022-08-03T14:04:14","slug":"clinical-dimensions-and-the-limbic-system","status":"publish","type":"page","link":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/?page_id=1692","title":{"rendered":"Clinical Dimensions and the Limbic System"},"content":{"rendered":"\n<p><strong>Family risk of alcohol addiction<\/strong> :\u00a0<\/p>\n\n\n\n<p style=\"text-align: justify;\">Differences between individuals with (FH+), and without (FH-), family history of alcohol use disorders: grey matter volumes (blue) and activity changes (vert, rouge) when anticipating a reward (\u00a9 Filippi et Coll, European Psychiatry 2019) :<\/p>\n<p><a href=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/risque-familial.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-1776 aligncenter\" src=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/risque-familial-300x217.jpg\" alt=\"\" width=\"477\" height=\"345\" srcset=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/risque-familial-300x217.jpg 300w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/risque-familial-768x556.jpg 768w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/risque-familial.jpg 944w\" sizes=\"(max-width: 477px) 100vw, 477px\" \/><\/a><\/p>\n\n\n\n<p style=\"text-align: justify;\"><strong>Medication-resistant depression<\/strong>. Increased limbic amygdala volume was not related to medication or bipolar or unipolar status. This suggests an MRI biomarker of vulnerability to <strong>chronicity<\/strong>, revealed by medication resistance (\u00a9 Sandu et al., Depress Anxiety. 2017) :<\/p>\n<p><a href=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/chronicite.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-1777 aligncenter\" src=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/chronicite-278x300.jpg\" alt=\"\" width=\"336\" height=\"363\" srcset=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/chronicite-278x300.jpg 278w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/chronicite.jpg 567w\" sizes=\"(max-width: 336px) 100vw, 336px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\"><strong>Lithium and depression<\/strong>. Higher grey matter volume in the superior and middle frontal gyrus bilaterally in lithium-treated patients compared to the lithium-free group (\u00a9 Sandu et al., Depress Anxiety. 2017) :<\/p>\n<p><a href=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/lithium.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-1778 aligncenter\" src=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/lithium-290x300.jpg\" alt=\"\" width=\"333\" height=\"344\" srcset=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/lithium-290x300.jpg 290w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/lithium.jpg 567w\" sizes=\"(max-width: 333px) 100vw, 333px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\"><strong>Hypodopaminergic and depression. <\/strong>Decreased dopamine transporter in patients treated for major depression (MMD) compared to control subjects (HC). Midbrain (blue) and right dorsal putamen (\u00a9 Dubol et al., JAD 2019) :<\/p>\n<p><a href=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/hypodopaminergie.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-1779 aligncenter\" src=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/hypodopaminergie-300x126.jpg\" alt=\"\" width=\"543\" height=\"228\" srcset=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/hypodopaminergie-300x126.jpg 300w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/hypodopaminergie-1024x429.jpg 1024w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/hypodopaminergie-768x322.jpg 768w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/hypodopaminergie.jpg 1387w\" sizes=\"(max-width: 543px) 100vw, 543px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\"><strong>Cross-diagnostic relationship<\/strong>. A correlation between activation during a task soliciting the reward system and the dopamine transporter in the nucleus accumbens was detected in all diagnostic groups studied &#8211; adults with major depression, &#8211; schizophrenia, or &#8211; cocaine addiction (\u00a9 Dubol et Coll., Neuropsychopharmacology 2018) :<\/p>\n<p><a href=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/fmri-contrast.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-1780 aligncenter\" src=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/fmri-contrast-300x209.jpg\" alt=\"\" width=\"400\" height=\"279\" srcset=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/fmri-contrast-300x209.jpg 300w, https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/fmri-contrast.jpg 733w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Family risk of alcohol addiction :\u00a0 Differences between individuals with (FH+), and without (FH-), family history of alcohol use disorders: grey matter volumes (blue) and activity changes (vert, rouge) when anticipating a reward (\u00a9 Filippi et Coll, European Psychiatry 2019) : Medication-resistant depression. Increased limbic amygdala volume was not related to medication or bipolar or &hellip; <a href=\"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/?page_id=1692\" class=\"more-link\">Continuer la lecture de <span class=\"screen-reader-text\">Clinical Dimensions and the Limbic System<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1686,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/1692"}],"collection":[{"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1692"}],"version-history":[{"count":4,"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/1692\/revisions"}],"predecessor-version":[{"id":1844,"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/1692\/revisions\/1844"}],"up":[{"embeddable":true,"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/1686"}],"wp:attachment":[{"href":"https:\/\/www.inserm-u1000.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}